Hello! Yes, I do believe geographical region matters. I am still learning but I believe that there are several factors to to consider when consuming wheat such as type of wheat, milling process, and herbicides used. Here is an article that lists where the herbicide glyphosate is banned. That would probably be a good first step. Some people truly don't seem to be affected by wheat consumption. But, our needs can be as individual as we are, meaning there is no one size fits all solution to eating well. I hope this helps. Thanks for dropping by. -Aimee